Jeff,
In my opinion, no. Heavy protein skimming won't minimize the number of regular water changes required. Remember that the water changes also replace trace minerals in addition to removing contaminates.
With that said, I've heard of people that run large systems and haven't done a water change in over a year.
For our system, I see it as cheap insurance for our livestock and feel it helps with the overall health of our corals. We also have 6 clams and they are very picky about their water.
Doug



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